Pemafibrate decreases triglycerides and small, dense LDL, but increases LDL-C depending on baseline triglycerides and LDL-C in type 2 diabetes patients with hypertriglyceridemia: an observational study
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چکیده
منابع مشابه
LDL pattern and correlation between LDL size and HDL-C, Triglyceride in type II diabetic patients compared with normal individuals
Introduction: Low density lipoprotein particles are non homogenous in terms of their density and composition. Type B pattern is characterized by predominance of small dense LDL particles. Investigations indicate that small dense LDL is associated with an increased risk of coronary artery disease (CAD). This study is designed to recognize additional effective parameter which could perhaps cont...
متن کاملSmall dense LDL is more susceptible to glycation than more buoyant LDL in Type 2 diabetes.
Glycation of apoB (apolipoprotein B) of LDL (low-density lipoprotein) increases its atherogenicity. Concentrations of both serum glyc-apoB (glycated apoB) and SD-LDL (small dense LDL) (syn LDL3; D=1.044-1.063 g/ml) are increased in diabetes and are closely correlated. We studied whether SD-LDL is more susceptible to glycation in vitro than more buoyant LDL in statin- and non-statin-treated Type...
متن کاملSmaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients
BACKGROUND Small dense low density lipoprotein (sdLDL) has recently emerged as an important risk factor of coronary heart disease. METHODS The mean LDL particle size was measured in 203 patients with type 2 diabetes mellitus (T2DM) and 212 matched subjects without diabetes using polyacrylamide tube gel electrophoresis. Major vascular complications were defined as stroke, angiographically-docu...
متن کاملOxidized LDL is Correlated with Urine Albumin in Type 2 Diabetes Mellitus: A Case-Control Study
Objective: In patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. We designed a study for comparing the level of Ox-LDL in diabetic patients with Macro-albuminuria, Micro-albuminuria, versus Normo-albuminuric. Materials and Methods: One hundred and thirty five patients with type 2 dia...
متن کاملEffects of Small Dense LDL in Diabetic Nephropathy in Females with Type 2 Diabetes Mellitus
Objective: This study investigated the association between small-dense low-density lipoprotein (sdLDL) and diabetic nephropathy (DN) in type 2 diabetic patients. Methods: A total of 172 type 2 diabetic patients (95 men and 77 women) who had not taken lipid-lowering agents were enrolled in this study. Measured LDL cholesterol fractionates into seven parts (LDL1 through 7) according to the size a...
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ژورنال
عنوان ژورنال: Lipids in Health and Disease
سال: 2021
ISSN: 1476-511X
DOI: 10.1186/s12944-021-01434-8